Thanks to large-scale international projects, a series of functional markers are continuously surveyed across human cell types and organisms. The challenge is to integrate and distribute efficiently this multi-layered data.
Transposable Elements have been associated to binding site complexes, epigenetic changes, gene expression and non-coding RNA. How to identify functional TEs from the ones creating biochemical noise?
Genome rearrangements can have a high functional impact but are still difficult to detect with sequencing technologies. Regions with genomic repeats are enriched in structural variants but even more challenging.
Meet The Lab
Director of Bioinformatics, McGill University & Genome Quebec Innovation Center
Toby Dylan Hocking
Machine learning models of genomic data.
Time-series multi-omics analysis of responses to influenza vaccines in collaboration with Kyoto University.
Copy-Number Variant Detection in Low-Mappability Regions.
Detection of L1 insertion from long-read sequencing.
Epigenetic conservation across species and transposable elements evolution.
Mapping functional transposable elements in primate immune cells.
Our Latest Work
The lab is currently recruiting postdocs and graduate students.
Background in programming or statistics is a must and experience in quantitative biology is a plus.
If you are interested please email your CV and the outline of a research project.